As Conference of Parties (COP29) convenes in Baku, Azerbaijan from 11st to 22nd November 2024, the globe is greatly impacted by the accelerating impacts of climate change with floods, droughts, hurricanes, and heatwaves after human lives and ecosystem in addition to destruction of infrastructure and properties. These effects are felt most in the poorest and most vulnerable nations and communities especially in Africa which lack the resources to adapt and protect themselves. The impact of climate change has not spared the Health sector with destruction of health infrastructure, health commodities and loss of lives in Africa with flooding affecting Southern and East African countries, drought ravaging Horn of Africa and the Sahel Region countries in Africa, Water-borne and Malaria diseases affecting countries in Central, West and Southern Africa.