The World Health Organization (WHO) recognizes the importance of collaborating with civil society to achieve health for all and meet the objectives outlined in its General Programme of Work. To enhance this engagement, the WHO has established the Civil Society Commission (CSO Commission), a network to strengthen dialogue, foster collaboration, and provide recommendations to support WHO's interactions with civil society at various levels. This article examines the mission, status, vision, objectives, principles, structure, and functions of the CSO Commission, highlighting its significance in advancing global health and the Sustainable Development Goals (SDGs).